CYLINDER PLATE ASSAY AND SOME STUDIES OF ISONICOTINIC ACID HYDRAZIDE WITH M. TUBERCULOSIS 607

Isonicotinic Acid Hydrazide

Isonicotinic acid hydrazide (rimifon) in the treatment of tuberculosis.

Following reports on the effectiveness of isonicotinic acid hydrazide in the treatment of tuberculosis,’ a clinical trial was instituted at the San Angel Sanatorium in Mexico City. Beginning in March 1952, a series of 13 hospitalized and 12 ambulatory patients were started on therapy with Rlmifon* and the results evaluated at the end of a 90-day period. The hospitalized patients selected for st...

Synthesis and structural studies of complexes of Cu, Co, Ni and Zn with isonicotinic acid hydrazide and isonicotinic acid (1-naphthylmethylene)hydrazide

Eight new complexes of Cu(II), Co(II), Ni(II) and Zn(II) with isonicotinic acid hydrazide (isoniazid, (INH)) and isonicotinic acid (1-naphthylmethylene)hydrazide (INNMH), having the formula of the type [M(INH)(ac)2] or [M(INNMH)(ac)2] (M = Co(II), Ni(II) and Zn(II)) and [Cu(INH)(ac)2]2, [Cu(INNMH)(ac)2]2, were synthesized and characterized. All complexes were characterized based on elemental an...

[First clinical results in the treatment of pulmonary tuberculosis with isonicotinic acid hydrazide].

Application of isonicotinic acid hydrazide and related compounds under the name Rimifon, Nicotibine, Tizide, Ditubine, was carried out in a total number of 160 cases in the University Clinic of Phthisiology of Athens at the Sanatorium “Sotiria”. The present study concerns only 36 cases of pulmonary tuberculosis of which four had tuberculous laryngitis. The limited number of 36 selected cases ou...

Tuberculosis of the Skin—Assessment of Clinical and Histological Changes Following Isonicotinic Acid Hydrazide Therapy

Diet.?Non-vegetarian. Clinical Findings.?Moderately nourished boy. The lesion presented itself as a raised area on the right thigh just below the inguinal region, 4^-" X 34" in size. Edge was hypopigmented. The centre was more raised than the border and had a warty appearance and feel. Moderate amount of crusting in one or two areas near the centre. Similar lesion on the right foot, involving t...